Orchard trial lung cancer
WebTrial Description: This is a study of the efficacy, pharmacokinetics, and safety of DS-1062a in participants with advanced or metastatic non-small cell lung cancer (NSCLC) with known actionable genomic alterations. Conditions: non-small … WebClinical Trials Open Actively Recruiting Phase 2 Platform Study in Patients With Advanced Non-Small Lung Cancer Who Progressed on First-Line Osimertinib Therapy (ORCHARD) …
Orchard trial lung cancer
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WebORCHARD (NCT03944772) is a phase II study aiming to characterize first-line osimertinib resistance and identify post-progression treatments. Methods: Adults aged ≥ 18 years … WebOct 19, 2024 · ORCHARD is an open-label, multicentre, multi-drug Phase II platform trial in patients with advanced EGFRm NSCLC whose disease has progressed on 1st-line therapy …
WebSep 14, 2024 · BOSTON and LONDON, Sept. 14, 2024 (GLOBE NEWSWIRE) -- Orchard Therapeutics (Nasdaq: ORTX), a global gene therapy leader, today will present on the … WebApr 8, 2024 · Diagnosis of Non-Squamous Non-Small Cell Lung Cancer; Receipt of at least one but not more than two prior treatment regimens in the advanced setting; Prior treatment with PD-1/PD-L1 checkpoint inhibitor therapy and platinum-based chemotherapy in combination or in sequence (i.e., platinum-based chemotheraphy followed by checkpoint …
WebHealth Professionals What is the purpose of this trial? Phase 2 Platform Study in Patients with Advanced Non-Small Lung Cancer who progressed on First-Line Osimertinib Therapy. … WebSep 1, 2024 · 1239P ORCHARD osimertinib + savolitinib interim analysis: A biomarker-directed phase II platform study in patients (pts) with advanced non-small cell lung cancer (NSCLC) whose disease has ...
WebJul 8, 2024 · The standard of care is to treat such patients with chemotherapy or chemotherapy plus immunotherapy such as Impower 150 regimen. A phase 2 ORCHARD …
WebNov 1, 2024 · Introduction. Osimertinib, a third-generation, irreversible, epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI), selectively inhibits both EGFR-TKI sensitizing (EGFRm) and EGFR T790M resistance mutations and has demonstrated efficacy in non-small cell lung cancer (NSCLC) CNS metastases. Most patients with EGFRm … buffer\\u0027s 7sWebMay 10, 2024 · This is an open-label, multicentre, multi-drug, biomarker-directed Phase 2 platform study in patients with advanced non-small cell lung cancer (NSCLC) harbouring … crockett county jail inmate searchWebThe NCI-sponsored National Lung Screening Trial (NLST) showed that low-dose CT scans can be used to screen for lung cancer in people with a history of heavy smoking. Using this screening can decrease their risk of dying from lung cancer. Now researchers are looking for ways to refine CT screening to better predict whether cancer is present. buffer\\u0027s 82WebHowever, part B enrollment was terminated early owing to an increased incidence of interstitial lung disease (ILD)-related adverse events (AEs). Safety (primary objective) and preliminary anti-tumor activity determined by objective response rate (ORR), best overall response, duration of response (DOR), and progression-free survival were evaluated. buffer\u0027s 7tWebApr 11, 2024 · Lung cancer is one of the leading causes of cancer death worldwide, and about 85% of lung cancer is non–small cell lung cancer (NSCLC) [1, 2].Especially the prognosis for lung cancer is often poor because most patients have already been in the advanced stage at the time of diagnosis [].However, this situation has been partly … buffer\\u0027s 7yWebNov 1, 2024 · Current Trial Report. ... both EGFR-TKI sensitizing (EGFRm) and EGFR T790M resistance mutations and has demonstrated efficacy in non-small cell lung cancer (NSCLC) CNS metastases. Most patients with EGFRm NSCLC treated with osimertinib will eventually develop resistance. ... ORCHARD (NCT03944772) is a phase II study aiming to … buffer\\u0027s 7tWebClinical Trials. NCI funds and oversees both early- and late-phase clinical trials to develop new treatments and improve patient care. Trials are available for both non-small cell lung … crockett county jail phone number